Review on Landmark Discovery of GPCR heterodimers published by Prof. Quitterer in 2019

The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers. But during the last two decades it was increasingly recognized that GPCRs can undergo aggregation to form dimers and higher order oligomers. We contributed to this paradigm shift in GPCR pharmacology by the discovery of the first pathologic GPCR aggregation, which is the protein complex formation between the angiotensin II AT1 receptor and the bradykinin B2 receptor. The history of this findings is shown in the published review article which can be accessed by the following link:
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external pagehttps://www.frontiersin.org/articles/10.3389/fmed.2019.00009/fullcall_made